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| Untersuchte Arbeit: Seite: 21, Zeilen: 10-13 |
Quelle: Fontanari Krause 2006 Seite(n): 22, Zeilen: 13-17 |
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| 1.6.3 Protein tyrosine kinase fusion partners of ETV6
The first identified fusion partner of ETV6 was a protein tyrosine kinase (PTK), the platelet-derived growth factors receptor beta (PDGFRB) (Golub et. al., 1994). The fusion protein critical for the development of the chronic myelo-[monocytic leukemia is the ETV6/PDGFRB fusion and not the reciprocal PDGFRB/ETV6 fusion.] Golub, T. R., Barker, G. F., Lovett, M., and Gilliland, D. G. (1994). Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 77, 307-316. |
4.3.3. Protein tyrosine kinase fusion partners of ETV6
The first identified fusion partner of ETV6 was a protein tyrosine kinase (PTK), the platelet-derived growth factors receptor beta (PDGFRB) (Golub, 1994a). The fusion protein critical for the development of the chronic myelomonocytic leukemia is the ETV6/PDGFRB fusion, and not the reciprocal PDGFRB/ETV6 fusion. Golub, T. R., Barker G.F., Lovett M., Gilliland D. G. (1994a). Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell. 77 (2), 307-16. |
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