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| Untersuchte Arbeit: Seite: 21, Zeilen: 10-13 |
Quelle: Bohlander 2005 Seite(n): 163, Zeilen: r.col: 29-36 |
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| 1.6.3 Protein tyrosine kinase fusion partners of ETV6
The first identified fusion partner of ETV6 was a protein tyrosine kinase (PTK), the platelet-derived growth factors receptor beta (PDGFRB) (Golub et. al., 1994). The fusion protein critical for the development of the chronic myelo-[monocytic leukemia is the ETV6/PDGFRB fusion and not the reciprocal PDGFRB/ETV6 fusion.] Golub, T. R., Barker, G. F., Lovett, M., and Gilliland, D. G. (1994). Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 77, 307-316. |
5. Protein tyrosine kinase fusion partners of ETV6
The first fusion partner of ETV6 was a protein tyrosine kinase (PTK), the platelet-derived growth factors receptor beta [3]. The fusion protein that is critical for the development of the chronic myelomonocytic leukemia and that has shown considerable transformation potential in cell line assays is the ETV6/PDGFRB fusion and not the reciprocal PDGFRB/ETV6 fusion. [3] Golub TR, Barker GF, Lovett M, Gilliland DG. Fusion of PDGF receptor ß to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 1994;77:307–16. |
The source is not mentioned here. The copied text continues on the next page Vpr/Dublette/Fragment_022_01. Note that the most likely source is different, see: Vpr/Fragment_021_10 |
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