Androgen Receptor and PIN1 in Prostate Cancer
von Dott. Raffaele La Montagna
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| [1.] Rlm/Fragment 028 01 - Diskussion Zuletzt bearbeitet: 2014-12-03 07:49:42 Singulus | BauernOpfer, Chen et al 2006, Fragment, Gesichtet, Rlm, SMWFragment, Schutzlevel sysop |
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| Untersuchte Arbeit: Seite: 28, Zeilen: 1 ff. (entire page) |
Quelle: Chen et al 2006 Seite(n): 929, Zeilen: 10-14 |
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| Recently has been demonstrated that Androgen receptor (AR) interacts with β-catenin and can suppress its coactivation of T cell factor 4 (Tcf4) in prostate cancer (PCa) cells. Pin1 is a peptidyl-prolyl cis/trans isomerase that stabilizes β-catenin by inhibiting its binding to the adenomatous polyposis coli gene product and subsequent glycogen synthase kinase 3β (GSK-3β)-dependent degradation. Higher Pin1 expression in primary PCa is correlated with disease recurrence, and this study found that Pin1 expression was markedly increased in metastatic PCa.(48).
48) Shao-Yong Chen, Gerburg Wulf,Xiao Zhen Zhou,Mark A. Rubin, Kun Ping Lu, and Steven P. Balk .Activation of "-Catenin Signaling in Prostate Cancer by Peptidyl-Prolyl Isomerase Pin1-Mediated Abrogation of the Androgen Receptor–"-Catenin Interaction. Mol Cell Biol. 2006 Feb;26(3):929-39 |
Androgen receptor (AR) interacts with β-catenin and can suppress its coactivation of T cell factor 4 (Tcf4) in prostate cancer (PCa) cells. Pin1 is a peptidyl-prolyl cis/trans isomerase that stabilizes β-catenin by inhibiting its binding to the adenomatous polyposis coli gene product and subsequent glycogen synthase kinase 3β (GSK-3β)-dependent degradation. Higher Pin1 expression in primary PCa is correlated with disease recurrence, and this study found that Pin1 expression was markedly increased in metastatic PCa. |
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Letzte Bearbeitung dieser Seite: durch Benutzer:Singulus, Zeitstempel: 20141203075034
Letzte Bearbeitung dieser Seite: durch Benutzer:Singulus, Zeitstempel: 20141203075034