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| Autor | J. Kevin Leach, Glenn Van Tuyle, Peck-Sun Lin, Rupert Schmidt-Ullrich, Ross B. Mikkelsen |
| Titel | Ionizing Radiation-induced, Mitochondria-dependent Generation of Reactive Oxygen/Nitrogen |
| Zeitschrift | Cancer Research |
| Ausgabe | 61 |
| Datum | 15. May 2001 |
| Seiten | 3894-3901 |
| URL | http://cancerres.aacrjournals.org/content/61/10/3894.full.pdf |
Literaturverz. |
yes |
| Fußnoten | yes |
| Fragmente | 1 |
| [1.] Iam/Fragment 077 21 - Diskussion Zuletzt bearbeitet: 2014-03-12 19:32:30 Graf Isolan | Fragment, Gesichtet, Iam, Leach et al 2001, SMWFragment, Schutzlevel sysop, Verschleierung |
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| Untersuchte Arbeit: Seite: 77, Zeilen: 21-29 |
Quelle: Leach et al 2001 Seite(n): 3899, Zeilen: r.col: 13-21, 25-28 |
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| Ionizing radiation initiates an oxidative event within a mitochondrion that results in the localized release of Ca2+. Adjacent mitochondria take up the Ca2+ and, as a consequence, undergo the mitochondrial permeability transition and release Ca2+ to further propagate the signal to adjacent mitochondria. Elevated mitochondrial Ca2+ levels and/or direct current (DC) depolarization can enhance mitochondrial ROS generation (Vercesi et al. 1997). This explanation could support our data as mitochondrial damage was also observed in our model. In dividing cells, a substantial fraction of the cellular mitochondria are recruited to and concentrated near the nucleus as part of the mitochondrial replication component of cell division (Davis and Clayton 1996).
Davis AF, Clayton DA (1996) In situ localization of mitochondrial DNA replication in intact mammalian cells. J Cell Biol 135:883-893 Vercesi AE, Kowaltowski AJ, Grijalba MT, Meinicke AR, Castilho RF (1997) The role of reactive oxygen species in mitochondrial permeability transition. Biosci Rep 17:43-52 |
In this model, ionizing radiation initiates an oxidative event within a mitochondrion that results in the localized release of Ca2+. Adjacent mitochondria take up the Ca2+ and, as a consequence, undergo the mitochondrial permeability transition (exemplified by ΔΨ depolarization) and release Ca2+ to further propagate the signal to adjacent mitochondria. Elevated mitochondrial Ca2+ levels and/or ΔΨ depolarization can enhance mitochondrial ROS/RNS generation (34), although this may not be the only source of elevated ROS/RNS, as discussed below.
[...] In dividing cells, a substantial fraction of the cellular mitochondria are recruited to and concentrated near the nucleus as part of the mitochondrial replication component of cell division (38). 34. Vercesi, A. E., Kowaltowski, A. J., Grijalba, M. T., Meinicke, A. R., and Castilho, R. F. The role of reactive oxygen species in mitochondrial permeability transition. Biosci. Rep., 17: 43–52, 1997. 38. Davis, A., and Clayton, D. In situ localization of mitochondrial DNA replication in intact mammalian cells. J. Cell Biol., 135: 883–893, 1996. |
The source is mentioned a bit further up, but with no indication whatsoever that further down a passage is taken from it verbatim and including references to the literature. Note: copying ΔΨ and pasting it leads naturally to "DC". |
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