Angaben zur Quelle [Bearbeiten]
| Autor | Andreas Busjahn, Atakan Aydin, Regina Uhlmann, Christine Krasko, Sylvia Bähring, Tamas Szelestei, Yuxi Feng, Stephan Dahm, Arya M. Sharma, Friedrich C. Luft, Florian Lang |
| Titel | Serum- and Glucocorticoid-Regulated Kinase (SGK1) Gene and Blood Pressure |
| Zeitschrift | Hypertension |
| Ausgabe | 40 |
| Jahr | 2002 |
| Seiten | 256-260 |
| URL | http://hyper.ahajournals.org/content/40/3/256.full.pdf |
Literaturverz. |
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| Fußnoten | yes |
| Fragmente | 1 |
| [1.] Dsa/Fragment 022 02 - Diskussion Zuletzt bearbeitet: 2016-08-20 19:07:12 WiseWoman | Busjahn et al 2002, Dsa, Fragment, Gesichtet, KomplettPlagiat, SMWFragment, Schutzlevel sysop |
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| Untersuchte Arbeit: Seite: 22, Zeilen: 2-14 |
Quelle: Busjahn et al 2002 Seite(n): 256, Zeilen: l.col: 1ff |
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| The serum- and glucocorticoid-regulated kinase (SGK) was originally cloned from rat mammary tumor cells as a glucocorticoid responsive gene. The human isoform was subsequently cloned as a cell volume–sensitive gene upregulated by both hypertonic and isotonic cell shrinkage (Waldegger S. et al., (1997) Proc Natl Acad Sci; Waldegger S. et al., (2000) Cell Physiol Biochem).
Because of the discovery of the 2 isoforms SGK2 and SGK3 (Kobayashi T. et al., (1999) Biochem J) the originally cloned kinase is labeled SGK1. SGK1 is expressed in renal tubular epithelial cells (Naray-Fejes-Toth A. et al., (1999) J Biol Chem; Loffing J. et al., (2001) Am J Physiol Renal Physiol) and its transcription is strongly stimulated by mineralocorticoids (Chen SY. et al., (1999) Proc Natl Acad Sci USA) suggesting a role in renal Na+ regulation. Indeed, coexpression of SGK1 with the renal epithelial Na+ channel (ENaC), in Xenopus oocytes markedly upregulates Na+ channel activity by enhancing channel protein abundance in the cell membrane. |
The serum- and glucocorticoid-regulated kinase (SGK) was originally cloned from rat mammary tumor cells as a glucocorticoid responsive gene.1 The human isoform was subsequently cloned as a cell volume–sensitive gene upregulated by both hypertonic and isotonic cell shrinkage.2,3 Because of the discovery of the 2 isoforms SGK2 and SGK3,4 the originally cloned kinase is labeled SGK1. SGK1 is expressed in renal tubular epithelial cells,5,6 and its transcription is strongly stimulated by mineralocortcoids,7 suggesting a role in renal Na+ regulation. Indeed, coexpression of SGK1 with the renal epithelial Na+ channel (ENaC) in Xenopus oocytes markedly upregulates Na+ channel activity by enhancing channel protein abundance in the cell membrane.5–9
1. Webster MK, Goya L, Ge Y, Maiyar AC, Firestone GL. Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol Cell Biol. 1993;13:2031–2040. 2. Waldegger S, Barth P, Raber G, Lang F. Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume. Proc Natl Acad Sci U S A. 1997;94:4440–4445. 3. Waldegger S, Gabrysch S, Barth P, Fillon S, Lang F. h-sgk serine threonine protein kinase as transcriptional target of p38/MAP kinase pathway in HepG2 human hepatoma cells. Cell Physiol Biochem. 2000;10:203–208. 4. Kobayashi T, Deak M, Morrice N, Cohen P. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. Biochem J. 1999;344:189–197. 5. Naray-Fejes-Toth A, Canessa C, Cleaveland ES, Aldrich G, Fejes-Toth G. Sgk is an aldosterone-induced kinase in the renal collecting duct: effects on epithelial Na+ channels. J Biol Chem. 1999;274:16973–16978. 6. Loffing J, Zecevic M, Feraille E, Kaissling B, Asher C, Rossier BC, Firestone GL, Pearce D, Verrey F. Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK. Am J Physiol Renal Physiol. 2001;280:F675–F682. 7. Chen SY, Bhargava A, Mastroberardino L, Meijer OC, Wang J, Buse P, Firestone GL, Verrey F, Pearce D. Epithelial sodium channel regulated by aldosterone-induced protein sgk. Proc Natl Acad Sci U S A. 1999;96: 2514–2519. 8. Bohmer C, Wagner CA, Beck S, Moschen V, Melzig J, Werner A, Lin JT, Lang F, Wehner F. The shrinkage-activated Na+ conductance of rat hepatocytes and its possible correlation to rENaC. Cell Physiol Biochem. 2000;10: 187–194. 9. Wagner CA, Ott M, Klingel K, Beck S, Melzig J, Friedrich B, Wild KN, Broer S, Moschen I, Albers A, Waldegger S, Tummler B, Egan ME, Geibel JP, Kandolf R, Lang F. Effects of the serine/threonine kinase SGK1 on the epithelial Na+ channel (ENaC) and CFTR: implications for cystic fibrosis. Cell Physiol Biochem. 2001;11:209–218. |
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