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| Autor | Peter ten Dijke, Helen M. Arthur |
| Titel | Extracellular control of TGFβ signalling in vascular development and disease |
| Zeitschrift | Nature Reviews Molecular Cell Biology |
| Herausgeber | Nature Publishing Group |
| Ausgabe | 8 |
| Datum | November 2007 |
| Seiten | 857-869 |
| DOI | 10.1038/nrm2262 |
| URL | http://www.nature.com/nrm/journal/v8/n11/full/nrm2262.html |
Literaturverz. |
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| Fußnoten | yes |
| Fragmente | 1 |
| [1.] Arc/Fragment 030 01 - Diskussion Zuletzt bearbeitet: 2014-02-26 22:35:32 Schumann | Arc, Fragment, Gesichtet, SMWFragment, Schutzlevel sysop, Ten Dijke Arthur 2007, Verschleierung |
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| Untersuchte Arbeit: Seite: 30, Zeilen: 1-5 |
Quelle: Ten Dijke Arthur 2007 Seite(n): 863, Zeilen: figure caption |
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| In sprouting angiogenesis, endothelial cells proliferate behind the tip cell of a growing branch in response to cytokines, such as VEGF, and lumens can form by vacuole fusion. Both forms of angiogenesis require the recruitment of smooth muscle cells (SMCs) to stabilize the nascent vessels.
Fig. 7 – Representation of vasculogenesis and two types of angiogenesis: intussusceptive and sprouting angiogenesis. Vasculogenesis involves the differentiation of endothelial cells (ECs) from precursor angioblast cells to form a primitive plexus of capillaries, which remodel and grow by angiogenesis. Intussusceptive angiogenesis involves the splitting and growing of vessels in situ. Vessel splitting occurs by the formation of translumen pillars (arrowheads) but the molecular mechanisms are not well understood74. 74. Risau W. Mechanisms of angiogenesis. Nature. 1997;386:671-674. |
Figure 3 TGFβ signalling in vasculogenesis and angiogenesis. Vasculogenesis and two types of angiogenesis are shown: intussusceptive and sprouting angiogenesis (BOX 1). Vasculogenesis involves the differentiation of endothelial cells (ECs) from precursor angioblast cells to form a primitive plexus of capillaries, which remodel and grow by angiogenesis. Intussusceptive angiogenesis involves the splitting and growing of vessels in situ in a metabolically efficient manner, and is found, for example, in the developing yolk sac and lung. Vessel splitting occurs by the formation of translumen pillars (arrowheads) but the molecular mechanisms are not well understood. In sprouting angiogenesis, endothelial cells proliferate behind the tip cell of a growing branch in response to cytokines such as vascular endothelial growth factor (VEGF) and lumens can form by vacuole fusion. Both forms of angiogenesis require the recruitment of smooth muscle cells (SMCs) to stabilize the nascent vessels. |
The source is not mentioned here. Risau (1997) does not contain the copied material. |
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