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Autor     George G. Somjen
Titel    Mechanisms of spreading depression and hypoxic spreading depression-like depolarization
Zeitschrift    Physiological Reviews
Herausgeber    American Physiological Society
Ausgabe    81
Jahr    2001
Nummer    3
Seiten    1065-1096
URL    http://physrev.physiology.org/content/physrev/81/3/1065.full.pdf

Literaturverz.   

yes
Fußnoten    yes
Fragmente    1


Fragmente der Quelle:
[1.] Aeh/Fragment 006 17 - Diskussion
Zuletzt bearbeitet: 2014-04-30 06:07:45 PlagProf:-)
Aeh, Fragment, Gesichtet, SMWFragment, Schutzlevel sysop, Somjen 2001, Verschleierung

Typus
Verschleierung
Bearbeiter
Hindemith
Gesichtet
Yes
Untersuchte Arbeit:
Seite: 6, Zeilen: 17-25
Quelle: Somjen 2001
Seite(n): 1066, 1067, Zeilen: 1066: r.col: last 3 lines; 1067: l.col: 1ff
The first paper on SD, titled "Spreading depression of activity in the cerebral cortex" appeared in 1944, written by a Brazilian neuroscientist, Aristides Leão, working at the Harvard laboratory. Leão wanted to study the electrocorticogram (ECoG) of experimental epilepsy in anesthetized rabbits, but he was distracted from his original goal by an unexpected flattening of the ongoing normal bioelectrical activity that took the place of the anticipated epileptiform field potentials. The silencing of the ECoG trace crept slowly over the cortex, from one recording electrode pair resting on the cortical surface to the one beside it. According to Leão, SD and propagating focal seizures were related phenomena, generated by the same cellular elements, an inference later supported by others. The first, seminal paper on SD, titled “Spreading depression of activity in the cerebral cortex” (213) appeared in 1944, written by a young and unknown Brazilian inves-

[page 1067]

tigator, Aristides Leão, working at the Harvard laboratory of R. S. Morison. Leão wanted to study the cortical electrogram (ECoG) of experimental epilepsy in anesthetized rabbits, but he was distracted from his original goal by an unexpected silencing of the ongoing normal electrical activity that took the place of the anticipated seizure (Fig. 1). The flattening of the ECoG trace crept slowly over the cortex, from one recording electrode pair resting on the cortical surface to the one beside it. According to Leão, SD and propagating focal seizures were related phenomena, generated by the same cellular elements (213), an inference later supported by others (e.g., Ref. 428).


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Anmerkungen

The source is indicated in the bibliographry, but no reference is made in the present context.

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