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| Autor | A. Gorji, D. Scheller, E-J. Speckmann |
| Titel | The Lateral Spread of Epileptiform Discharges in Rat Neocortical Slices: Effect of Focal Phencyclidine Application |
| Zeitschrift | Pharmacopsychiatry |
| Verlag | Georg Thieme Verlag |
| Ausgabe | 36 |
| Jahr | 2003 |
| Seiten | 113-120 |
| ISSN | 0176-3679 |
| URL | https://www.thieme-connect.com/DOI/DOI?10.1055/s-2003-39986 |
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| Fußnoten | no |
| Fragmente | 3 |
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| Cortical structures are organized to process information in a parallel manner via excitatory and inhibitory interactions within and between adjacent cortical modules (Mountcastle, 1997). Throughout the CNS, local circuit inhibition plays an integral role in both neuronal network processing and the regulation of the excitability of projection neurons.
Mountcastle VB. The columnar organization of the neocortex. Brain 1997; 120: 701-722. |
Cortical structures are organized to process information in a parallel manner via excitatory and inhibitory interactions within and between adjacent cortical modules [33]. Throughout the CNS, local circuit inhibition plays an integral role in both neuronal network processing and the regulation of the excitability of projection neurons.
33 Mountcastle VB. The columnar organization of the neocortex. Brain 1997; 120: 701-722 |
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| [Inhibitory circuits may] be particularly important to signal processing in cortical networks with pronounced recurrent excitatory interactions (Wong et al., 1984). This inhibition may limit the lateral spread of excitation and facilitate discharge synchronization of projection neurons by inducing a synchronous refractory period. Breakdown in the dynamic balance of inhibitory and excitatory interaction can lead to a functional disconnection (Wong and Prince, 1990) and disrupts the normal spread of lateral excitation (Grunze et al., 1996).
Grunze HC, Rainnie DG, Hasselmo ME, Barkai E, Hearn EF, McCarley RW, Greene RW. NMDA-dependent modulation of CA1 local circuit inhibition. J Neurosci 1996; 16: 2034-2043. Wong BY, Prince DA. The lateral spread of ictal discharges in neocortical brain slices. Epilepsy Res 1990; 7: 29-39. Wong RK, Miles R, Traub RD. Local circuit interactions in synchronization of cortical neurones. J Exp Biol 1984; 112: 169-178. |
Inhibitory circuits may be particularly important to signal processing in cortical networks with pronounced recurrent excitatory interactions [53]. This inhibition may limit the lateral spread of excitation and facilitate discharge synchronization of projection neurons by inducing a synchronous refractory period. Breakdown in the dynamic balance of inhibitory and excitatory interaction can lead to a functional disconnection [52] and disrupts the normal spread of lateral excitation [20].
20 Grunze HC, Rainnie DG, Hasselmo ME, Barkai E, Hearn EF, McCarley RW, Greene RW. NMDA-dependent modulation of CA1 local circuit inhibition. J Neurosci 1996; 16: 2034-2043 52 Wong BY, Prince DA. The lateral spread of ictal discharges in neocortical brain slices. Epilepsy Res 1990; 7: 29-39 53 Wong RK, Miles R, Traub RD. Local circuit interactions in synchronization of cortical neurones. J Exp Biol 1984; 112: 169-178 |
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| Electrophysiological recordings
Simultaneous extracellular field potentials were recorded via two glass microelectrodes (150 mmol/L NaCl; 2 - 10 MΩ) positioned at approximately 5-10 mm intervals across the length of the slice in the third cortical layer (figure 2). The reference electrode and the connection to the microelectrode were symmetric Ag-Ag-KCl bridges. Field potentials were traced by an ink writer and recorded by a digital oscilloscope. Inter-electrode distances were measured with a calibrated eyepiece through the microscope. |
Electrophysiological recordings
Simultaneous extracellular field potentials were recorded via four glass microelectrodes (150 mmol/L NaCl; 2 - 10 MΩ) positioned at approximately 2 - 3 mm intervals across the length of the slice in the third cortical layer. [...] The reference electrode and the connection to the microelectrode were symmetric Ag-Ag-KCl bridges. Field potentials were traced by an ink writer and recorded by a digital oscilloscope. Inter-electrode distances were measured with a calibrated eyepiece through the microscope. |
The source is not mentioned. In the abstract, on page 5 (8ff), one can read: |
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