Angaben zur Quelle [Bearbeiten]
| Autor | Jeffery D. Molkentin, Jian-Rong Lu, Christopher L. Antos, Bruce Markham, James Richardson, Jeffrey Robbins, Stephen R. Grant, Eric N. Olson |
| Titel | A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy |
| Zeitschrift | Cell |
| Verlag | Cell Press |
| Ausgabe | 93 (2) |
| Datum | 17. April 1998 |
| Seiten | 215–228 |
| DOI | 10.1016/S0092-8674(00)81573-1 |
| URL | http://www.cell.com/abstract/S0092-8674(00)81573-1, http://www4.utsouthwestern.edu/olsonlab/publications/4.pdf |
Literaturverz. |
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| Fußnoten | nein |
| Fragmente | 1 |
| [1.] Analyse:Aa/Fragment 007 02 - Diskussion Zuletzt bearbeitet: 2013-01-22 19:11:24 Graf Isolan | Aa, Fragment, Molkentin et al 1998, SMWFragment, Schutzlevel, Verschleierung, ZuSichten |
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| Untersuchte Arbeit: Seite: 7, Zeilen: 2-9 |
Quelle: Molkentin et al 1998 Seite(n): 215, Zeilen: re.Sp. 21-32 |
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| In response to myocyte stretch or increased loads on working heart preparations, intracellular Ca2+ concentration increases (Marban et al., 1987; Bustamante et al., 1991; Hongo et al., 1995), consistent with a role of Ca2+ in coordinating physiologic responses with enhanced cardiac output. A variety of humoral factors, including phenylephrine (PE), which induce the hypertrophic response in cardiomyocytes (Karliner et al., 1990; Sadoshima and Izumo, 1993; Sadoshima et al., 1993; Leite et al., 1994), also share the ability to elevate intracellular Ca2+ concentrations.
Bustamante JO, Ruknudin A and Sachs F (1991) Stretch-activated channels in heart cells: relevance to cardiac hypertrophy. J Cardiovasc Pharmacol 17: S110–S113. Hongo K, White E, Gannier F, Argibay JA Garnier D and Orchard CH (1995) Effect of stretch on contraction and the Ca2+ transient ferret ventricular muscles during hypoxia and acidosis. Am J Physiol 269: C690–C697. Karliner JS, Kariya T and Simpson PC (1990) Effects of pertussis toxin on α1-agonist-mediated phosphatidylinositide turnover and myocardial cell hypertrophy in neonatal rat myocytes. Experientia 46: 81–84. Leite MF, Page E and Ambler S K (1994) Regulation of ANP secretion by endothelin-1 in cultured atrial myocytes: desensitization and receptor subtype. Am J Physiol 267: H2193–H2203. Marban E, Kitakaze M, Kusuoka H, Porterfield JK, Yue DT and Chacko VP (1987) Intracellular free calcium concentrations measured with 19F NMR spectroscopy in intact ferret hearts. Proc Natl Acad Sci USA 84: 6005–6009. Sadoshima J, and Izumo S (1993) Signal transduction pathways of angiotensin II-induced c-fos gene expression in cardiac myocytes in vitro. Circ Res 73: 424–438. Sadoshima J, Xu Y, Slayter HS and Izumo S (1993) Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell 75: 977–984. |
In response to myocyte stretch or increased loads on working heart preparations, intracellular Ca2+ concentrations increase (Marban et al., 1987; Bustamante et al., 1991; Hongo et al., 1995), consistent with a role of Ca2+ in coordinating physiologic responses with enhanced cardiac output. A variety of humoral factors, including angiotensin II (AngII), phenylephrine (PE), and endothelin-1 (ET-1), which induce the hypertrophic response in cardiomyocytes (Karliner et al., 1990; Sadoshima and Izumo, 1993; Sadoshima et al., 1993; Leite et al., 1994), also share the ability to elevate intracellular Ca2+ concentrations.
Bustamante, J.O., Ruknudin, A., and Sachs, F. (1991). Stretch-activated channels in heart cells: relevance to cardiac hypertrophy. J. Cardiovasc. Pharmacol. 17, S110–S113. Hongo, K., White, E., Gannier, F., Argibay, J.A., Garnier, D. (1995). Orchard CH effect of stretch on contraction and the Ca2+ transient ferret ventricular muscles during hypoxia and acidosis. Am. J. Physiol. 269, C690–C697. Karliner, J.S., Kariya, T., and Simpson, P.C. (1990). Effects of pertussis toxin on α1-agonist-mediated phosphatidylinositide turnover and myocardial cell hypertrophy in neonatal rat myocytes. Experientia 46, 81–84. Leite, M.F., Page, E., and Ambler, S.K. (1994). Regulation of ANP secretion by endothelin-1 in cultured atrial myocytes: desensitization and receptor subtype. Am. J. Physiol. 267, H2193–H2203. Marban, E., Kitakaze, M., Kusuoka, H., Porterfield, J.K., Yue, D.T., and Chacko, V.P. (1987). Intracellular free calcium concentrations measured with 19F NMR spectroscopy in intact ferret hearts. Proc. Natl. Acad. Sci. USA. 84, 6005–6009 Sadoshima, J., and Izumo, S. (1993). Signal transduction pathways of angiotensin II-induced c-fos gene expression in cardiac myocytes in vitro. Circ. Res. 73, 424–438. Sadoshima, J., Xu, Y., Slayter, H.S., and Izumo, S. (1993). Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell 75, 977–984. |
Identisch bis hin zu den Literaturverweisen. Übernahmen bleiben ungekennzeichnet. |
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