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Autor     Fernando Macián, Carmen García-Rodríguez, Anjana Rao
Titel    Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun
Zeitschrift    The EMBO Journal
Ausgabe    19 (17)
Datum    September 2000
Seiten    4783–4795
DOI    10.1093/emboj/19.17.4783
URL    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC302068/#cdd458c54

Literaturverz.   

ja
Fußnoten    ja
Fragmente    1


Fragmente der Quelle:
[1.] Analyse:Aa/Fragment 008 06 - Diskussion
Zuletzt bearbeitet: 2013-01-21 23:54:57 Graf Isolan
Aa, BauernOpfer, Fragment, Macian et al 2000, SMWFragment, Schutzlevel, ZuSichten

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BauernOpfer
Bearbeiter
Graf Isolan
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Untersuchte Arbeit:
Seite: 8, Zeilen: 6-11, 13-15
Quelle: Macian et al 2000
Seite(n): 4783, Zeilen: 0
In cells of the immune system, cooperative NFAT–AP-1 complexes are induced by stimulation of the antigen receptors of T and B cells, Fcγ receptors of macrophages and natural killer (NK) cells (Rao et al., 1997). These receptors are coupled on the one hand to calcium mobilization and on the other hand to activation of PKC/RAS pathways (Van Leeuwen and Samelson, 1999). [...] Therefore, even in a single cell type NFAT activation can evoke two distinct biological programs of gene expression that depending on AP-1 absence or presence (Macian et al., 2000).

Rao A, Luo C and Hogan PG (1997) Transcription factor of the NFAT family: regulation and function. Annu Rev Immunol 15: 707-747.

Van Leeuwen JE and Samelson LE (1999) T-cell antigen-receptor signal transduction. Curr Opin Immunol 1: 242-248.

Our results support the hypothesis that even in a single cell type, NFAT activation can evoke two distinct biological programs of gene expression, dependent or independent of NFAT–AP-1 cooperation. [...]

In cells of the immune system, cooperative NFAT–AP-1 complexes are induced by stimulation of the antigen receptors of T and B cells, the Fcγ receptors of macrophages and natural killer (NK) cells, and the Fcε receptors of mast cells and basophils (Rao et al., 1997). These receptors are coupled on the one hand to calcium mobilization and on the other hand to activation of protein kinase C (PKC)/Ras/Raf/MAP kinase pathways (van Leeuwen and Samelson, 1999).


Rao A., Luo,C. and Hogan,P.G. (1997) Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol., 15, 707–747.

van Leeuwen J.E. and Samelson,L.E. (1999) T cell antigen-receptor signal transduction. Curr. Opin. Immunol., 11, 242–248.

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Patchwork aus wortwörtlich übernommenen Texten, ohne dass die Übernahmen gekennzeichnet worden wären. Die angegebenen Literaturstellen stimmen ebenfalls überein.

"Macian et al., 2000" wird im Literaturverzeichnis von Aa nicht aufgeschlüsselt.

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