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| Autor | Fernando Macián, Carmen García-Rodríguez, Anjana Rao |
| Titel | Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun |
| Zeitschrift | The EMBO Journal |
| Ausgabe | 19 (17) |
| Datum | September 2000 |
| Seiten | 4783–4795 |
| DOI | 10.1093/emboj/19.17.4783 |
| URL | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC302068/#cdd458c54 |
Literaturverz. |
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| Fußnoten | ja |
| Fragmente | 1 |
| [1.] Analyse:Aa/Fragment 008 06 - Diskussion Zuletzt bearbeitet: 2013-01-21 23:54:57 Graf Isolan | Aa, BauernOpfer, Fragment, Macian et al 2000, SMWFragment, Schutzlevel, ZuSichten |
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| Untersuchte Arbeit: Seite: 8, Zeilen: 6-11, 13-15 |
Quelle: Macian et al 2000 Seite(n): 4783, Zeilen: 0 |
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| In cells of the immune system, cooperative NFAT–AP-1 complexes are induced by stimulation of the antigen receptors of T and B cells, Fcγ receptors of macrophages and natural killer (NK) cells (Rao et al., 1997). These receptors are coupled on the one hand to calcium mobilization and on the other hand to activation of PKC/RAS pathways (Van Leeuwen and Samelson, 1999). [...] Therefore, even in a single cell type NFAT activation can evoke two distinct biological programs of gene expression that depending on AP-1 absence or presence (Macian et al., 2000).
Rao A, Luo C and Hogan PG (1997) Transcription factor of the NFAT family: regulation and function. Annu Rev Immunol 15: 707-747. Van Leeuwen JE and Samelson LE (1999) T-cell antigen-receptor signal transduction. Curr Opin Immunol 1: 242-248. |
Our results support the hypothesis that even in a single cell type, NFAT activation can evoke two distinct biological programs of gene expression, dependent or independent of NFAT–AP-1 cooperation. [...]
In cells of the immune system, cooperative NFAT–AP-1 complexes are induced by stimulation of the antigen receptors of T and B cells, the Fcγ receptors of macrophages and natural killer (NK) cells, and the Fcε receptors of mast cells and basophils (Rao et al., 1997). These receptors are coupled on the one hand to calcium mobilization and on the other hand to activation of protein kinase C (PKC)/Ras/Raf/MAP kinase pathways (van Leeuwen and Samelson, 1999). Rao A., Luo,C. and Hogan,P.G. (1997) Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol., 15, 707–747. van Leeuwen J.E. and Samelson,L.E. (1999) T cell antigen-receptor signal transduction. Curr. Opin. Immunol., 11, 242–248. |
Patchwork aus wortwörtlich übernommenen Texten, ohne dass die Übernahmen gekennzeichnet worden wären. Die angegebenen Literaturstellen stimmen ebenfalls überein. "Macian et al., 2000" wird im Literaturverzeichnis von Aa nicht aufgeschlüsselt. |
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