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| Autor | Kenta Ito, Xinhua Yan, Xin Feng, Warren J. Manning, Wolfgang H. Dillmann, Beverly H. Lorell |
| Titel | Transgenic Expression of Sarcoplasmic Reticulum Ca2+ ATPase Modifies the Transition From Hypertrophy to Early Heart Failure |
| Zeitschrift | Circulation Research |
| Jahr | 2001 |
| Jahrgang | 89 |
| Seiten | 422-429 |
| DOI | doi: 10.1161/hh1701.095522 |
| URL | http://circres.ahajournals.org/content/89/5/422.full |
Literaturverz. |
ja |
| Fußnoten | ja |
| Fragmente | 1 |
| [1.] Analyse:Aa/Fragment 013 05 - Diskussion Zuletzt bearbeitet: 2013-04-08 23:29:51 Graf Isolan | Aa, Fragment, Ito et al 2001, SMWFragment, Schutzlevel, Verschleierung, ZuSichten |
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| Untersuchte Arbeit: Seite: 13, Zeilen: 5-10 |
Quelle: Ito et al 2001 Seite(n): 422, Zeilen: left col. 4-9 |
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| Over expression of SERCA2a using an adenoviral gene transfer technique transiently enhances cardiac contractile function and SR Ca2+ uptake (Giordano et al., 1997; Miyamoto et al., 2000). Enhanced contractility has also been reported in SERCA-over expressing transgenic mice not subjected to pathological stimuli (He et al., 1997; Baker et al., 1998).
Giordano FJ, He H, McDonough P, Meyer M, Sayen MR, Dillmann WH (1997) Adenovirus-mediated gene transfer reconstitutes depressed sarcoplasmic reticulum Ca2+-ATPase levels and shortens prolonged cardiac myocyte Ca2+ transients. Circulation 96: 400–403. Miyamoto MI, Del Monte F, Schmidt U, DiSalvo TS, Kang ZB, Matsui T, Guerrero JL, Gwathmey JK, Rosenzweig A, Hajjar RJ (2000) Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure. Proc Natl Acad Sci USA 97: 793–798. He H, Giordano FJ, Hilal-Dandan R, Choi D-J, Rockman HA, McDonough PM, Bluhm WF, Meyer M, Sayen MR, Swanson E, Dillmann WH (1997) Over expression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation. J Clin Invest 100: 380–389. Baker D, Hashimoto K, Grupp I, Ji Y, Reed T, Loukianov E, Grupp G, Bhagwhat A, Hoit B, Walsh R, Marbán E, Periasamy M (1998) Targeted over expression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts. Circ Res 83: 1205–1214. |
We and others have reported that overexpression of SERCA2a using an adenoviral gene transfer technique transiently enhances cardiac contractile function and SR Ca2+ uptake.3,4 Enhanced contractility has also been reported in otherwise normal TG mice not subjected to pathological stimuli.5,6
3. Giordano FJ, He H, McDonough P, Meyer M, Sayen MR, Dillmann WH. Adenovirus-mediated gene transfer reconstitutes depressed sarcoplasmic reticulum Ca2+-ATPase levels and shortens prolonged cardiac myocyte Ca2+ transients. Circulation. 1997;96:400–403. 4. Miyamoto MI, Del Monte F, Schmidt U, DiSalvo TS, Kang ZB, Matsui T, Guerrero JL, Gwathmey JK, Rosenzweig A, Hajjar RJ. Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure. Proc Natl Acad Sci U S A. 2000;97:793–798. 5. He H, Giordano FJ, Hilal-Dandan R, Choi D-J, Rockman HA, McDonough PM, Bluhm WF, Meyer M, Sayen R, Swanson E, Dillmann WH. Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation. J Clin Invest. 1997;100:380 –389. 6. Baker D, Hashimoto K, Grupp I, Ji Y, Reed T, Loukianov E, Grupp G, Bhagwhat A, Hoit B, Walsh R, Marbán E, Periasamy M. Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts. Circ Res. 1998;83: 1205–1214. |
Trotz wörtlicher Übereinstimmung (bis hin zu den Literaturverweisen) kein Hinweis auf eine Übernahme. Fragment komplementiert Aa/Fragment_013_02. |
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