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| Untersuchte Arbeit: Seite: 69, Zeilen: 10-24 |
Quelle: Holt 2000 Seite(n): S151, Zeilen: left col. 13-15, 20-27, 32-42 |
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| 4.4 Antigen presentation in the lung
The epithelial surfaces of the lungs and conducting airways are continuously exposed to mixtures of antigens present in ambient air. The adaptive immune system in the lung is faced with the task of accurately categorizing these stimuli, such that T cell responses that are qualitatively appropriate for neutralization of each agent are selected. Secondarily, it must tightly control the intensity and duration of these responses, in order to preserve the integrity of the fragile, highly vascularized epithelial surfaces in the organ, particularly those at which gas exchange occurs. The epithelial surfaces within the major conducting airways in which the majority of inhaled antigen is deposited are protected via the scrubbing action of the overlying mucociliary escalator, and the small proportion of inhaled antigen that escapes this mechanism and penetrates into the underlying epithelial layer is then dealt with via specialized antigen-presenting cells (APC), in particular Dendritic cell (DC) populations, within and below the epithelium. The alveolar surfaces in the deep lung are policed instead by macrophage populations, again backed up to APC population below the alveolar epithelium. |
[page S151]
The epithelial surfaces of the lungs and conducting airways are continuously exposed to mixtures of antigens present in ambient air. [...] The adaptive immune system in the lung is faced with the task of accurately categorizing these stimuli, such that T cell responses that are qualitatively appropriate for neutralization of each agent are selected. Secondarily, it must tightly control the intensity and duration of these responses, in order to preserve the integrity of the fragile, highly vascularized epithelial surfaces in the organ, particularly those at which gas exchange occurs. [...] The epithelial surfaces within the major conducting airways in which the bulk of inhaled antigen is deposited are protected via the scrubbing action of the overlying mucociliary escalator, and the small proportion of inhaled antigen that escapes this mechanism and penetrates into the underlying epithelial layer is then dealt with via specialized antigen-presenting cells (APCs), in particular dendritic cell (DC) populations, within and below the epithelium. The alveolar surfaces in the deep lung are policed instead by macrophage populations, again backed up by APC populations below the alveolar epithelium. |
No source given, nothing has been marked as a citation. These paragraphs are not part of the 2017 Erratum of Mag. |
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