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| Untersuchte Arbeit: Seite: 27, Zeilen: 21-29 |
Quelle: Bluestone_Abbas_2003 Seite(n): 256, Zeilen: l.col: 11-28 |
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| The two subsets of regulatory T cells might function in different immunological settings, depending on the context of antigen exposure, the nature of the inflammatory response and the T cell receptor (TCR) repertoires of the individual cells. The natural Treg cells are probably most effective at suppressing autoreactive T cell responses locally, in non-inflammatory settings – circumstances in which antigen specific, self limiting reactions are required to achieve a fine homeostatic balance. In contrast, during self-damaging inflammatory reactions to microbes or transplanted tissue, or settings (for example inflammatory bowel disease), adaptive Treg cells might be induced to suppress the pathological immune responses. | The two TReg-cell subsets might function in different immunological settings, depending on the context of antigen exposure, the nature of the inflammatory response and the TCR repertoires of the individual cells. We argue that natural TReg cells would be most effective at suppressing autoreactive T-cell responses locally, in non-inflammatory settings — circumstances in which antigen-specific, self-limiting reactions are required to achieve a fine homeostatic balance. By contrast, during self-damaging inflammatory reactions to microbes or transplanted tissue, or in settings of inflammatory autoimmune disease that are more similar to the infectious setting (for example, inflammatory bowel disease), adaptive TReg cells might be induced to suppress the pathological immune responses. |
No indication of the source. |
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