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| Untersuchte Arbeit: Seite: 16, Zeilen: 16-22 |
Quelle: Fehrenbach 2001 Seite(n): 42, Zeilen: l.col: 19-25 |
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| Additionally, AECII were reported to inhibit lymphocyte proliferation in vitro without altering their activation state (Paine et al., 1991). Moreover, AECII derived TGF-β (Zissel et al., 2000) could indirectly inhibit T cell proliferation via blockade of activating factors, such as IL-2. In contrast, granulocyte macrophage-colony stimulating factor (GM-CSF) released at the basolateral surface of AECII could increase the potential of dendritic cells to induce T-cell proliferation (Christensen et al., 1995).
Christensen PJ, Armstrong LR, Fak JJ, Chen GH, McDonald RA, Toews GB, Paine R 3rd. Regulation of rat pulmonary dendritic cell immunostimulatory activity by alveolar epithelial cell-derived granulocyte macrophage colony-stimulating factor. Am J Respir Cell Mol Biol. 1995 Oct; 13 (4): 426-33. Paine R 3rd, Mody CH, Chavis A, Spahr MA, Turka LA, Toews GB. Alveolar epithelial cells block lymphocyte proliferation in vitro without inhibiting activation. Am J Respir Cell Mol Biol. 1991 Sep; 5 (3): 221-9. Zissel G, Ernst M, Rabe K, Papadopoulos T, Magnussen H, Schlaak M, Muller-Quernheim J. Human alveolar epithelial cells type II are capable of regulating T-cell activity. J Investig Med. 2000 Jan; 48 (1): 66-75. |
AE2 cells were reported to inhibit lymphocyte proliferation in vitro without altering their activation state [172]. AE2-cell-derived TGF-β [170] may indirectly inhibit T-cell proliferation via blockade of activating factors, such as IL-2. In contrast, GM-CSF released at the basolateral surface of AE2 cells may increase the potential of dendritic cells to induce T-cell proliferation [166].
166. Christensen PJ, Armstrong LR, Fak JJ, Chen GH, McDonald RA, Toews GB, Paine R III: Regulation of rat pulmonary dendritic cell immunostimulatory activity by alveolar epithelial cellderived granulocyte macrophage colony- stimulating factor. Am J Respir Cell Mol Biol 1995, 13:426–433. 170. Zissel G, Ernst M, Rabe K, Papadopoulos T, Magnussen H, Schlaak M, Müller-Quernheim J: Human alveolar epithelial cells type II are capable of regulating T-cell activity. J Investig Med 2000, 48:66–75. 172. Paine R III, Mody CH, Chavis A, Spahr MA, Turka LA, Toews GB: Alveolar epithelial cells block lymphocyte proliferation in vitro without inhibiting activation. Am J Respir Cell Mol Biol 1991, 5:221–229. |
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