Crosstalk between autoreactive T cells and alveolar type II epithelial cells in inflammation and tolerance
von Dr. Marcus Gereke
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| [1.] Mag/Fragment 086 05 - Diskussion Zuletzt bearbeitet: 2014-03-16 17:02:38 Hindemith | BauernOpfer, Boyton and Openshaw 2002, Fragment, Gesichtet, Mag, SMWFragment, Schutzlevel sysop |
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| Untersuchte Arbeit: Seite: 86, Zeilen: 5-6, 8-14 |
Quelle: Boyton and Openshaw 2002 Seite(n): 1, Zeilen: 8-16 (abstract) |
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| The respiratory tract is a fragile tissue with architecture that is finely designed for gas exchange. Due to this main function the lung is exposed to numerous pathogens and other harmful air pollutions and developed many mechanisms to prevent infectious and inflammations. In the first line of defence are structural mechanisms coming from barriers such as epithelial cell layers, mucus and cilia, which avoid the invasion of pathogens or antigens. A battery of mediators that constitute the innate response including lactoferin, lysozyme, collectins and defensins is followed. Activation of these molecules can lead directly to lysis of pathogens, or to destruction through opsonisation or the recruitment of inflammatory cells (Boyton et al., 2002).
Boyton RJ, Openshaw PJ. Pulmonary defences to acute respiratory infection. Br Med Bull. 2002; 61:1-12. Review. |
The immune response to respiratory infection must, therefore, be rapid and efficient. However, the respiratory tract is a fragile tissue with architecture that is finely designed for gas exchange, so that the price of excessive or inappropriate inflammatory responses may itself be very high. The first line of defence comes from barriers such as mucus and cilia, followed by a battery of mediators that constitute the innate response. These include lactoferrin, lysozyme, collectins and defensins. Activation of these molecules can lead directly to lysis of pathogens, or to destruction through opsonisation or the recruitment of inflammatory cells. |
Found in the chapter "Discussion" of the thesis. No part has been marked as a citation and for the reader it is not transparent to what extent the source has been used. |
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Letzte Bearbeitung dieser Seite: durch Benutzer:Hindemith, Zeitstempel: 20140316170132
Letzte Bearbeitung dieser Seite: durch Benutzer:Hindemith, Zeitstempel: 20140316170132