Crosstalk between autoreactive T cells and alveolar type II epithelial cells in inflammation and tolerance
von Dr. Marcus Gereke
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| [1.] Mag/Fragment 027 13 - Diskussion Zuletzt bearbeitet: 2014-03-10 13:25:36 Hindemith | Fragment, Gesichtet, KomplettPlagiat, Mag, OGarra and Vieira 2004, SMWFragment, Schutzlevel sysop |
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| Untersuchte Arbeit: Seite: 27, Zeilen: 13-17 |
Quelle: OGarra and Vieira 2004 Seite(n): 801, Zeilen: l.col: 19-23 |
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| Regulatory T cells may be defined as CD4+ T cells that inhibit immunopathology or autoimmune disease in vivo. Specifically, Treg cells include those able to suppress naïve T cell proliferation in vitro and to control CD4+ or CD8+ T cell numbers in vivo, in lymphopenic hosts. Two major Treg populations have been described so far, [...] | Treg cells may be defined as CD4+ T cells that inhibit immunopathology or autoimmune disease in vivo. Specifically, Treg cells include those able to suppress naive T-cell proliferation in vitro and to control CD4+ or CD8+ T-cell numbers in vivo, in lymphopenic hosts. Two major Treg populations have been described so far, [...]. |
The source is not mentioned here. |
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| [2.] Mag/Fragment 027 21 - Diskussion Zuletzt bearbeitet: 2014-03-10 13:25:28 Hindemith | Bluestone Abbas 2003, Fragment, Gesichtet, Mag, SMWFragment, Schutzlevel sysop, Verschleierung |
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| Untersuchte Arbeit: Seite: 27, Zeilen: 21-29 |
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| The two subsets of regulatory T cells might function in different immunological settings, depending on the context of antigen exposure, the nature of the inflammatory response and the T cell receptor (TCR) repertoires of the individual cells. The natural Treg cells are probably most effective at suppressing autoreactive T cell responses locally, in non-inflammatory settings – circumstances in which antigen specific, self limiting reactions are required to achieve a fine homeostatic balance. In contrast, during self-damaging inflammatory reactions to microbes or transplanted tissue, or settings (for example inflammatory bowel disease), adaptive Treg cells might be induced to suppress the pathological immune responses. | The two TReg-cell subsets might function in different immunological settings, depending on the context of antigen exposure, the nature of the inflammatory response and the TCR repertoires of the individual cells. We argue that natural TReg cells would be most effective at suppressing autoreactive T-cell responses locally, in non-inflammatory settings — circumstances in which antigen-specific, self-limiting reactions are required to achieve a fine homeostatic balance. By contrast, during self-damaging inflammatory reactions to microbes or transplanted tissue, or in settings of inflammatory autoimmune disease that are more similar to the infectious setting (for example, inflammatory bowel disease), adaptive TReg cells might be induced to suppress the pathological immune responses. |
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Letzte Bearbeitung dieser Seite: durch Benutzer:Graf Isolan, Zeitstempel: 20140310132950
Letzte Bearbeitung dieser Seite: durch Benutzer:Graf Isolan, Zeitstempel: 20140310132950