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| Untersuchte Arbeit: Seite: 18, Zeilen: 1-8 |
Quelle: Mohamed 2009 Seite(n): 19, 20, Zeilen: 19: 18 ff.; 20: 1 ff. |
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| [And (5) based on information gained through population structure, correlation of phenotypic and genotypic/haplotypic data with the application of an appropriate statistical approach that reveals, consequently a specific gene(s) controlling a] QTL of interest can be cloned using the marker tags and annotated for an exact biological function. Association mapping offers three main advantages: increased mapping resolution, reduced research time, and greater allele numbers (Reich et al. 2001).
Association mapping, also known as linkage disequilibrium mapping, is a relatively new and promising genetic method for complex trait dissection. Association mapping has the promise of higher mapping resolution through exploitation of historical recombination events at the population level that may enable gene level mapping on non-model organisms where linkage based approaches would not be feasible (Varshney and Tuberosa 2007). Reich DE, Cargill M, Bolk S et al. (2001) Linkage disequilibrium in the human genome. Nature, vol. 411, No. 6834: 199–204 Varshney RK and Tuberosa R (2007) Application of linkage disequilibrium and association mapping in crop plants. Genomics Approaches and Platforms, Vol 1: 97 – 119 |
And (5) based on information gained through population structure, correlation of phenotypic and genotypic/haplotypic data with the application of an appropriate statistical approach that reveals, consequently a specific gene(s) controlling a QTL of interest can be cloned using the marker tags and annotated for an exact biological function.
[...] Compared to linkage mapping in traditional bioparental populations, association mapping offers three main advantages: increased mapping resolution, reduced research time, and greater allele numbers (Reich et al. 2001). [page 20] Association mapping, also known as linkage disequilibrium mapping, is a relatively new and promising genetic method for complex trait dissection. Association mapping has the promise of higher mapping resolution through exploitation of historical recombination events at the population level that may enable gene level mapping on non-model organisms where linkage based approaches would not be feasible (Varshney and Tuberosa. 2007). Reich DE, Cargill M, Bolk S, Ireland J, Sabeti PC, Richter DJ, Lavery T, Kouyoumjian R, Farhadian S, Ward R, Lander ES (2001) Linkage disequilibrium in the human genome. Nature, vol. 411, No. 6834: 199–204 Varshney RK, Tuberosa R (2007) Application of linkage disequilibrium and association mapping in crop plants. Genomics Approaches and Platforms, Vol 1: 97 – 119. |
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