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| Untersuchte Arbeit: Seite: 19, Zeilen: 1-6 |
Quelle: Ebong et al 2006 Seite(n): H2015, Zeilen: r. Spalte: 16 ff. |
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| [Although the extent of combinations of different connexins within connexons and] channels remains unclear, immunohistochemical and immunocytochemical studies demonstrate differential expression and localization patterns of all three vascular connexins in the endothelium, depending on species[97], vascular bed[98-100], and local hemodynamics[101]. In vivo studies implicate Cx40 as the constitutive vascular gap junction protein across species and vascular bed, playing an important role in coupling between cells in the vascular wall[97].
97. van Kempen, M.J. and H.J. Jongsma, Distribution of connexin37, connexin40 and connexin43 in the aorta and coronary artery of several mammals. Histochem Cell Biol, 1999. 112(6): p. 479-86. 98. Hill, C.E., et al., Heterogeneity in the distribution of vascular gap junctions and connexins: implications for function. Clin Exp Pharmacol Physiol, 2002. 29(7): p. 620-5. 99. Pepper, M.S., et al., Coupling and connexin 43 expression in microvascular and large vessel endothelial cells. Am J Physiol, 1992. 262(5 Pt 1): p. C1246-57. 100. Yeh, H.I., et al., Individual gap junction plaques contain multiple connexins in arterial endothelium. Circ Res, 1998. 83(12): p. 1248-63. 101. Gabriels, J.E. and D.L. Paul, Connexin43 is highly localized to sites of disturbed flow in rat aortic endothelium but connexin37 and connexin40 are more uniformly distributed. Circ Res, 1998. 83(6): p. 636-43. |
Although the extent of combinations of different connexins within connexons and channels remains unclear, immunohistochemical and immunocytochemical studies demonstrate differential expression and localization patterns of all three vascular connexins in endothelium, depending on species (44), vascular bed (25, 37, 53), and local hemodynamics (21). In vivo studies implicate Cx40 as the constitutive vascular gap junction protein across species and vascular bed, playing an important role in coupling between cells in the vascular wall (44).
21. Gabriels JE and Paul DL. Connexin43 is highly localized to sites of disturbed flow in rat aortic endothelium but connexin37 and connexin40 are more uniformly distributed. Circ Res 83: 636–643, 1998. 25. Hill CE, Rummery N, Hickey H, and Sandow SL. Heterogeneity in the distribution of vascular gap junctions and connexins: implications for function. Clin Exp Pharmacol Physiol 29: 620–625, 2002. 37. Pepper MS, Montesano R, el Aoumari A, Gros D, Orci L, and Meda P. Coupling and connexin 43 expression in microvascular and large vessel endothelial cells. Am J Physiol Cell Physiol 262: C1246–C1257, 1992. 44. Van Kempen MJ and Jongsma HJ. Distribution of connexin37, connexin40 and connexin43 in the aorta and coronary artery of several mammals. Histochem Cell Biol 112: 479–486, 1999. 53. Yeh HI, Rothery S, Dupont E, Coppen SR, and Severs NJ. Individual gap junction plaques contain multiple connexins in arterial endothelium. Circ Res 83: 1248–1263, 1998. |
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