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| Untersuchte Arbeit: Seite: 6, Zeilen: 15-21 |
Quelle: Schaper and Scholz 2003 Seite(n): 1145, Zeilen: l. Spalte: 10 ff. |
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| FSS is proportional to the blood flow velocity and inversely related to the cube of the radius[41]. It is sensed by the endothelium, which, in response, changes the expression of growth factors, secretes nitric oxide (NO)[42, 43], prostacyclin, and probably other transmitters, and leads, with prolonged exposure, to positive arterial remodeling. However, even small increases in the radius of collateral arteries lead to a precipitous fall of the FSS because of the cubic relationship, and the FSS-related growth ends prematurely[20].
20. Schaper, W. and D. Scholz, Factors regulating arteriogenesis. Arterioscler Thromb Vasc Biol, 2003. 23(7): p. 1143-51. 41. Schmidt, V.J., et al., Gap junctions synchronize vascular tone within the microcirculation. Pharmacol Rep, 2008. 60(1): p. 68-74. 42. Busse, R. and I. Fleming, Regulation and functional consequences of endothelial nitric oxide formation. Ann Med, 1995. 27(3): p. 331-40. 43. Fleming, I., et al., Isometric contraction induces the Ca2+-independent activation of the endothelial nitric oxide synthase. Proc Natl Acad Sci U S A, 1999. 96(3): p. 1123-8. |
FSS is proportional to the blood flow velocity and inversely related to the cube of the radius.21 It is sensed by the endothelium, which, in response, changes the expression of growth factors, secretes NO,22,23 prostacyclin, and probably other transmitters, and leads, with prolonged exposure, to positive arterial remodeling. However, even small increases in the radius of collateral arteries lead to a precipitous fall of the FSS because of the cubic relationship, and the FSS-related growth ends prematurely.
21. Schmidt RF, Thews G. Physiologie des Menschen. Berlin: Springer; 1997. 22. Busse R, Fleming I. Regulation and functional consequences of endothelial nitric oxide formation. Ann Med. 1995;27:331–340. 23. Fleming I, Bauersachs J, Schäfer A, Scholz D, Aldershvile J, Busse R. Isometric contraction induces the Ca2+ independent activation of the endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 1999;96: 1123–1128. |
Die Quelle ist in Fn. 20 angegeben. Der Umfang der Übernahme, die drei Literaturverweise miteinschließt, wird aber ebensowenig deutlich wie der Umstand, dass es sich um eine beinahe wörtliche Übernahme handelt. |
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