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Arteriogenesis in Gja5 (Connexin-40) deficient mice

von Dr. Haitao Wang

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[1.] Haw/Fragment 014 01 - Diskussion
Zuletzt bearbeitet: 2014-10-23 19:44:46 [[Benutzer:|]]
BauernOpfer, Buschmann and Schaper 1999, Fragment, Gesichtet, Haw, SMWFragment, Schutzlevel sysop

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BauernOpfer
Bearbeiter
Hindemith
Gesichtet
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Untersuchte Arbeit:
Seite: 14, Zeilen: 1-8
Quelle: Buschmann and Schaper 1999
Seite(n): 124, 125, Zeilen: 124: r. Spalte: letzte Zeilen; 125: l. Spalte: 1ff
Arteriogenesis differs from angiogenesis in several aspects, (Table 1.1., Fig.1.5.) the most important being the dependence of angiogenesis on hypoxia and the dependence of arteriogenesis on inflammation[20]. However, angiogenesis and arteriogenesis share several mechanisms of action, e.g., their dependence on growth factors. Whereas angiogenesis can be largely explained by the actions of VEGF, arteriogenesis is probably a multifactorial process in which several growth factors are orchestrated. The role of VEGF in arteriogenesis is not clear, but a chemoattractive role for monocytes and hence an indirect contribution is imaginable[21].

20. Schaper, W. and D. Scholz, Factors regulating arteriogenesis. Arterioscler Thromb Vasc Biol, 2003. 23(7): p. 1143-51.

21. Buschmann, I. and W. Schaper, Arteriogenesis Versus Angiogenesis: Two Mechanisms of Vessel Growth. News Physiol Sci, 1999. 14: p. 121-125.

Arteriogenesis differs from angiogenesis in several aspects, the most important being the

[S. 125]

dependence of angiogenesis on hypoxia and the dependence of arteriogenesis on inflammation.

However, angiogenesis and arteriogenesis share several mechanisms of action (Fig. 2), e.g., their dependence on growth factors. Whereas angiogenesis can be largely explained by the actions of VEGF, arteriogenesis is probably a multifactorial process in which several growth factors are orchestrated. The role of VEGF in arteriogenesis is not clear, but a chemoattractive role for monocytes and hence an indirect contribution is imaginable.

Anmerkungen

Die Quelle ist angegeben, doch durch die Literaturverweise wird nicht klar, dass die gesamte Passage übernommen ist.

Sichter
(Hindemith), WiseWoman



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