Arteriogenesis in Gja5 (Connexin-40) deficient mice
von Dr. Haitao Wang
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| [1.] Haw/Fragment 003 04 - Diskussion Zuletzt bearbeitet: 2014-10-16 21:55:52 Singulus | BauernOpfer, Fragment, Gesichtet, Haw, Heil and Schaper 2004, SMWFragment, Schutzlevel sysop |
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| Untersuchte Arbeit: Seite: 3, Zeilen: 4-10 |
Quelle: Heil and Schaper 2004 Seite(n): 449, Zeilen: Abstract |
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| Growth of collateral blood vessels (arteriogenesis) is potentially able to preserve structure and function of limbs and organs after occlusion of a major artery. The success of the remodeling process depends on the following conditions: (1) existence of an arteriolar network that connects the preocclusive with the postocclusive microcirculation; (2) activation of the arteriolar endothelium by elevated fluid shear stress; (3) invasion (but not incorporation) of bone marrow–derived cells; and (4) proliferation of endothelial and smooth muscle cells[9].
9. Heil, M. and W. Schaper, Influence of mechanical, cellular, and molecular factors on collateral artery growth (arteriogenesis). Circ Res, 2004. 95(5): p. 449-58. |
Growth of collateral blood vessels (arteriogenesis) is potentially able to preserve structure and function of limbs and organs after occlusion of a major artery. The success of the remodeling process depends on the following conditions: (1) existence of an arteriolar network that connects the preocclusive with the postocclusive microcirculation; (2) activation of the arteriolar endothelium by elevated fluid shear stress; (3) invasion (but not incorporation) of bone marrow–derived cells; and (4) proliferation of endothelial and smooth muscle cells. |
Ein Verweis auf die Quelle steht am Ende des übernommenen Abschnittes, macht aber nicht klar, dass der gesamte Abschnitt wörtlich kopiert wurde. |
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| [2.] Haw/Fragment 003 16 - Diskussion Zuletzt bearbeitet: 2014-10-16 17:48:43 Singulus | Buschmann and Schaper 1999, Fragment, Gesichtet, Haw, SMWFragment, Schutzlevel sysop, Verschleierung |
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| Untersuchte Arbeit: Seite: 3, Zeilen: 16-26 |
Quelle: Buschmann and Schaper 1999 Seite(n): 122, Zeilen: l. Spalte: 36ff |
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| The presence of these native collaterals, which may not be utilized to provide perfusion under normal conditions, varies widely among species and also within individuals. However, these vessels have the ability to dramatically increase the lumen by growth so as to provide enhanced perfusion to the jeopardized ischemic regions. In case of chronic or acute occlusion of a major artery, collateral arteries can relieve the ensuing harmful effects in many regions of the body (hindlimb, heart, brain and kidney). It is important to recognize that this process is not a passive dilatation but one of active proliferation and remodeling. Under normal flow conditions and depending on the pressure gradient between the interconnecting arterial networks there is only minimal net forward flow, but small amounts of flow may oscillate within the network. | The presence of these native collaterals, which may not be utilized to provide perfusion under normal conditions, varies widely among species and also within individuals. However, these vessels have the ability to dramatically increase the lumen by growth so as to provide enhanced perfusion to the jeopardized ischemic regions. In case of chronic or acute occlusion of a major artery, collateral arteries can ameliorate the ensuing detrimental effects in many regions of the body (hindlimb, heart, brain, kidney). It is important to recognize that this process is not a passive dilatation but one of active proliferation and remodeling. Under normal flow conditions and depending on the pressure gradient between the interconnecting arterial networks there is only minimal net forward flow, but small amounts of flow may oscillate within the network. |
Ein Verweis auf die Quelle fehlt hier. Sie ist weiter oben genannt, aber ohne irgendeinen Hinweis, dass sich dieser Verweis auch auf die hier dokumentierte Passage beziehen soll. |
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| [3.] Haw/Fragment 003 27 - Diskussion Zuletzt bearbeitet: 2014-10-16 21:57:23 Singulus | BauernOpfer, Fragment, Gesichtet, Haw, Heil and Schaper 2004, SMWFragment, Schutzlevel sysop |
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| Untersuchte Arbeit: Seite: 3, Zeilen: 27-30 |
Quelle: Heil and Schaper 2004 Seite(n): 450, Zeilen: l. Spalte: 6ff |
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| Mature collateral vessels differ only in minor histological aspects from normal arteries of the conductance type: they are muscular and contain more collagen and exhibit transiently, during the growth process, a significant intima consisting of smooth muscle cells in the synthetic and proliferative phenotype. | Mature collateral vessels differ only in minor histological aspects from normal arteries of the conductance type: they are muscular and contain more collagen and exhibited transiently during the growth process a significant intima consisting of smooth muscle cells in the synthetic and proliferative phenotype. |
Ein Verweis auf die Quelle findet man weiter unten auf der nächsten Seite. Dieser Verweis macht keineswegs deutlich, dass die hier dokumentierte Passage wörtlich aus der Quelle stammt. |
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Letzte Bearbeitung dieser Seite: durch Benutzer:Singulus, Zeitstempel: 20141016215848
Letzte Bearbeitung dieser Seite: durch Benutzer:Singulus, Zeitstempel: 20141016215848