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| Untersuchte Arbeit: Seite: 60, Zeilen: 29-37 |
Quelle: Boini 2006 Seite(n): 35, Zeilen: 20ff |
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| The tail cuff method has the advantage to be noninvasive and can provide reproducible results of systolic blood pressure if those precautions are taken into account (Kurtz et al., (2005) Arterioscler Tromb Vasc Biol). Systolic arterial blood pressure was determined by the tail-cuff method (IITC, model 179, Woodland Hills, California, USA) before, 7 weeks and 12 weeks following the initiation of DOCA/high-salt treatment. As reviewed recently, (Meneton P et al., (2000) J Am Soc Neprhol), the tail cuff approach to determine arterial blood pressure requires certain precautions to reduce the stress of the animals, including appropriate training of the mice over multiple days and adequate prewarming to dilate the tail artery. | III. 3. Blood pressure: Systolic arterial blood pressure was determined by application of the tail-cuff method. As reviewed recently (Meneton et al., 2000), the tail cuff approach to determine arterial blood pressure requires certain precautions to reduce the stress of the animals, including appropriate training of the mice over multiple days, prewarming to an ambient temperature of 29°C, measurement in a quiet, semidarkend and clean environment, and performance of the measurements by one person and during a defined day time, when blood pressure is stable (between 1-3 PM). All these precautions were taken in the present study. The tail cuff method has the advantage to be noninvasive and can provide reproducible results of systolic blood pressure if those precautions are taken into account (Kurtz et al., 2005). |
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