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| Untersuchte Arbeit: Seite: 44, Zeilen: 1-14 |
Quelle: Saparov 2007 Seite(n): 1 (online source), Zeilen: - |
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| TRPV (vanilloid) family has six mammalian members grouped into three subfamilies. These proteins contain three to five ankyrin repeats and share ~25% amino acid identity to TRPC proteins (Montell C. et al, (2005) Sci STKE). TRPV1-TRPV4 form poor selective cation channels and are sensitive to heat (Hellwig N. et al., (2005) J Cell Sci). TRPV5 and TRPV6 are phylogenetically closely related Ca2+ selective channels (PCa: PNa > 100) expressed in epithelia of kidney and intestine and exhibit a constitutive activity (Clapham DE. et al., (2003) Pharmacol Rev). Both proteins become permeable to monovalent cations in the absence of divalent cations. It was proposed that TRPV6 may be the highly Ca2+-selective, store-operated channels, referred to CRAC but several biophysical properties of TRPV6 are distinct from those of ICRAC (Kahr H. et al., (2004) J Physiol). Nevertheless there remains still the option that TRPV5/ TRPV6 may be subunits of CRAC channels.
TRPM (long TRPC, melastatin) family is composed of eight members. They share ~20% identity, have a TRP domain and contain ankyrin repeats at the N-terminus which is longer than that of TRPCs and TRPVs (Fleig A. et al., (2004) Novartis Found Symp). |
TRPV (vanilloid) family has six mammalian members grouped into three subfamilies. These proteins contain three to five ankyrin repeats and share ~25% amino acid identity to TRPC proteins (1). TRPV1-TRPV4 form poor selective cation channels and are sensitive to heat (6,7). TRPV5 and TRPV6 are phylogenetically closely related Ca2+ selective channels (PCa:PNa > 100) expressed in epithelia of kidney and intestine and exhibit a constitutive activity. (3) Both proteins become permeable to monovalent cations in the absence of divalent cations. It was proposed that TRPV6 may be the highly Ca2+-selective, store-operated channels, referred to CRAC but several biophysical properties of TRPV6 are distinct from those of ICRAC (8). Nevertheless there remains still the option that TRPV5/ TRPV6 may be subunits of CRAC channels.(1)
TRPM (long TRPC, melastatin) family is composed of eight members. They share ~20% identity , have a TRP domain and contain ankyrin repeats at the N-terminus which is longer than that of TRPCs and TRPVs. (9) 1. Montell, C. (2005) Sci STKE 2005, re3 3. Clapham, D. E., Montell, C., Schultz, G., and Julius, D. (2003) Pharmacol Rev 55, 591-596 6. Hellwig, N., Albrecht, N., Harteneck, C., Schultz, G., and Schaefer, M. (2005) J Cell Sci 118, 917-928 7. Wang, H., and Woolf, C. J. (2005) Neuron 46, 9-12 8. Kahr, H., Schindl, R., Fritsch, R., Heinze, B., Hofbauer, M., Hack, M. E., Mortelmaier, M. A., Groschner, K., Peng, J. B., Takanaga, H., Hediger, M. A., and Romanin, C. (2004) J Physiol 557, 121-132 9. Fleig, A., and Penner, R. (2004) Novartis Found Symp 258, 248-258; discussion 258-266 |
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