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| Untersuchte Arbeit: Seite: 39, Zeilen: 1-6 |
Quelle: Boini 2006 Seite(n): 21, Zeilen: 2ff |
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| The in vivo significance of SGK1 in regulation of renal K+ transport was recently analyzed in SGK1 KO mice. These mice indeed show a disturbed adaptation to an acute and chronic K+ load, but, as indicated by electrophysiological and immunohistochemical data obtained from these mice after a chronic potassium load, this maladaptation likely is related to altered ENaC (or Na+, K+-ATPase) activity in the ASDN cells rather than to inhibition of ROMK cell surface targeting or activity (Huang DY. et al., (2004) J Am Soc Neprhol). | The in vivo significance of SGK1 in regulation of renal K+ transport was recently analyzed in SGK1 KO mice. These mice indeed show a disturbed adaptation to an acute and chronic K+ load, but, as indicated by electrophysiological and immunohistochemical data obtained from these mice after a chronic potassium load, this maladaptation likely is related to altered ENaC (or Na+,K+-ATPase) activity in the ASDN cells rather than to inhibition of ROMK cell surface targeting or activity (Huang et al., 2004). |
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