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| Untersuchte Arbeit: Seite: 22, Zeilen: 15-21 |
Quelle: Lang et al 2006 Seite(n): 1151, 1152, 1153, Zeilen: 1151: last lines; 1152: l.col: 20ff; 1153: r.col: 10ff |
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| SGK kinases are expressed in a wide variety of species including shark and Caenorhabditis elegans. Yeast expresses two orthologs, Ypk1 and Ypk2, which are involved in endocytosis and required for survival. Yeast lacking Ypk1 and Ypk2 can be rescued by mammalian SGK1. SGKs participate in the regulation of transport, hormone release, neuroexcitability, cell proliferation, and apoptosis.
Little is known about genomic regulation of SGK2 and SGK3, which appear to be less sensitive to hormonal regulation than SGK1. |
SGKs participate in the regulation of transport, hormone release, neuroexcitability, cell proliferation, and apoptosis.
[page 1152] SGK kinases are expressed in a wide variety of species including shark (348) and Caenorhabditis elegans (142). Yeast express two orthologs, Ypk1 and Ypk2, which are involved in endocytosis (87) and required for survival (60). Yeast lacking Ypk1 and Ypk2 can be rescued by mammalian SGK1 (60). [page 1153] Little is known about genomic regulation of SGK2 and SGK3, which appear to be less sensitive to hormonal regulation than SGK1 (182). 60. Casamayor A, Torrance PD, Kobayashi T, Thorner J, and Alessi DR. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol 9: 186–197, 1999. 87. DeHart AK, Schnell JD, Allen DA, and Hicke L. The conserved Pkh-Ypk kinase cascade is required for endocytosis in yeast. J Cell Biol 156: 241–248, 2002. 142. Hertweck M, Gobel C, and Baumeister R. C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev Cell 6: 577–588, 2004. 182. Lang F and Cohen P. Regulation and physiological roles of serumand glucocorticoid-induced protein kinase isoforms. Sci STKE 2001: RE17, 2001. 348. Waldegger S, Barth P, Forrest JN Jr, Greger R, and Lang F. Cloning of sgk serine-threonine protein kinase from shark rectal gland: a gene induced by hypertonicity and secretagogues. Pflügers Arch 436: 575–580, 1998 |
The source is not mentioned. |
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