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| Untersuchte Arbeit: Seite: 19, Zeilen: 11-23 |
Quelle: KidsNet Protein kinase 2007 Seite(n): 1 (online source), Zeilen: - |
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| - Protein kinase C: protein kinase C is actually a family of protein kinases that require Ca2+, diacylglycerol, and a phospholipid such as phosphatidylcholine for activation. Thus, protein kinase C is activated through the same signal transduction pathway as phospholipase C. At least twelve members of the protein kinase C family have been identified in mammals, due to their high sequence homology. The protein kinase C usually means the protein kinase Cα enzyme.
Structure and regulation Protein kinase C enzymes consist of an N-terminal regulatory domain and a C-terminal catalytic domain. The kinases are inactive in the absence of activating agents, due to autoinhibition of the regulatory domain. They can be activated tumor promoters such as tetradecanoyl-phorbol-acetate (TPA) or by the cofactors Ca2+, diacylglycerol and a phospholipid. The common linear structure of protein kinase C enzymes is: N-pseudosubstrate - TPA-binding - (Ca2+-binding) - ATP-binding - substrate-binding- C. |
Protein kinase C
Protein kinase C is actually a family of protein kinases that require Ca2+, diacylglycerol, and a phospholipid such as phosphatidylcholine[?] for activation. Thus, protein kinase C is activated through the same signal transduction pathway as phospholipase C. At least twelve members of the proteine kinase C family have been identified in mammals, due to their high sequence homology[?]. The protein kinase C usually means the protein kinase Cα enzyme. Structure and regulation Protein kinase C enzymes consist of an N-terminal regulatory domain and a C-terminal catalytic domain. The kinases are inactive in the absence of activating agents, due to autoinhibition of the regulatory domain. They can be activated tumor promotors such as tetradecanoyl-phorbol-acetate[?] (TPA) or by the cofactors Ca2+, diacylglycerol, and a phospholipid. The common linear structure of protein kinase C enzymes is: N - pseudosubstrate - TPA-binding - (Ca2+-binding) - ATP-binding - substrate-binding - C |
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