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| Untersuchte Arbeit: Seite: 18, Zeilen: 1-13 |
Quelle: Kinexus 2006 Seite(n): 1 (online source), Zeilen: - |
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| In the genome of the yeast Saccharomyces cerevisiae, protein kinases represent the largest family of related genes (121 out of 6144 yeast genes encode protein kinases). Many of these kinase genes have mammalian counterparts that will substitute for them in genetically re-engineered yeast. In the fly Drosophila melanogaster, 319 of its 13338 genes encode protein kinases. In the worm C. elegans, 437 of its 18266 genes specify protein kinases. For all of these organisms, this translates to approximately 2% of the total genes corresponding to protein kinases. Recently, the complete genome of the mustard plant Arabidopsis thaliana was reported and it features 1049 putative protein kinases out of 25706 genes. This represented about 4% of that plant's genome. The human genome appears to encode 500 protein kinases in addition to many pseudo-protein kinase genes, and these have been sub classified into over 57 families. There may well be additional protein kinases that remain to be identified. Protein kinases are readily recognized, because they feature characteristic amino acid sequences that distinguish these enzymes from other proteins. | In the genome of the yeast Saccharomyces cerevisiae, protein kinases represent the largest family of related genes (121 out of 6,144 yeast genes encode protein kinases). Many of these kinase genes have mammalian counterparts that will substitute for them in genetically re-engineered yeast. In the fly Drosophila melanogaster, 319 of its 13,338 genes encode protein kinases. In the worm C. elegans, 437 of its 18,266 genes specify protein kinases. For all of these organisms, this translates to approximately 2% of the total genes corresponding to protein kinases. Recently, the complete genome of the mustard plant Arabidopsis thal [sic] was reported, and it features 1049 putative protein kinases out of 25,706 genes. This represented about 4% of that plant's genome. The human genome appears to encode 510 protein kinases in addition to many pseudo-protein kinase genes, and these have been subclassified into over 57 families. There may well be additional protein kinases that remain to be identified. Protein kinases are readily recognized, because they feature characteristic amino acid sequences that distinguish these enzymes from other proteins. |
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