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| Untersuchte Arbeit: Seite: 24, Zeilen: 3-8 |
Quelle: Matharu et al 2004 Seite(n): 489, 491, Zeilen: 489: l.col: 10-14; 491: r.col: 31-36 |
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| Somatostatin has been shown to block the release of numerous vasoactive peptides, including Calcitonin Gene-Related Peptide and vasoactive intestinal polypeptide e et al.(Fassler et al., 1990; Helyes, 2001). Neurons containing somatostatin are found in the regions of the central and peripheral nervous system involved in nociception, such as peripheral sensory fibres, dorsal horn of the spinal cord, trigeminal nucleus caudalis, periaqueductal gray and the hypothalamus (Schindler et al., 1997).
Fassler JE, O'Dorisio TM, Mekhjian HS, Gaginella TS (1990) Octreotide inhibits increases in shortcircuit current induced in rat colon by VIP, substance P, serotonin and aminophylline. Regul Pept 29(2-3):189-97. Helyes Z, Pintér E, Németh J, Kéri G, Thán M, Oroszi G, Horváth A, Szolcsányi J (2001) Antiinflammatory effect of synthetic somatostatin analogues in the rat. Br J Pharmacol 134 (7):1571-9. Schindler M, Sellers LA, Humphrey PP, Emson PC (1997)Immunohistochemical localization of the somatostatin SST2(A) receptor in the rat brain and spinal cord. Neuroscience. 76(1):225-40. |
Somatostatin, an endogenously occurring 14–amino acid peptide, has been shown to inhibit the release of numerous vasoactive peptides, including CGRP19 and VIP.20
[page 491] Neurons containing somatostatin are found in the regions of the central and peripheral nervous system involved in nociception, such as peripheral sensory fibers, dorsal horn of the spinal cord, trigeminal nucleus caudalis, periaqueductal gray, and the hypothalamus.31,32 19. Helyes Z, Pinter E, Nemeth J, et al. Anti-inflammatory effect of synthetic somatostatin analogues in the rat. Br J Pharmacol 2001;134:1571–1579. 20. Fassler JE, O’Dorisio TM, Mekhjian HS, Gaginella TS. Octreotide inhibits increases in short-circuit current induced in rat colon by VIP, substance P, serotonin and aminophylline. Regul Pept 1990;29:189 –197. 31. Krisch B. Hypothalamic and extrahypothalamic distribution of somatostatin-immunoreactive elements in the rat brain. Cell Tissue Res 1978;195:499 –513. 32. Schindler M, Holloway S, Hathway G, et al. Identification of somatostatin sst2(a) receptor expressing neurones in central regions involved in nociception. Brain Res 1998;798:25–35. |
Also the passages after the here documented passage can be found in the source, but the match seems to be somewhat better with another paper by the same author, see Clg/Fragment_024_08. The source is given further down at the end of the paragraph but without indication that the whole paragraph is taken from it including several references to the literature. |
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