|
|
|
| Untersuchte Arbeit: Seite: 8, Zeilen: 1-4, 7-9 |
Quelle: Gorji 2001 Seite(n): 34, Zeilen: left col. 44-46 - right col. 1-7 |
|---|---|
| No explanation of the propagation of SD has been suggested that accounts for all the facts presently proven. The hypothesis that gained wide acceptance is that the spread of SD probably involves the release and diffusion of the chemical mediators, most likely K+ and glutamate into the interstitial fluid. [...] Given the widespread potential signaling capacities of Ca2+ waves, observations of the interactions between astrocytes and neurons in cell culture have suggested that Ca2+ waves play a role in SD initiation and propagation. | No explanation of the propagation of SD has been suggested that accounts for all the facts presently proven. The hypothesis that gained wide acceptance is that the spread of SD probably involves the release and diffusion of the chemical mediators, most likely K+ and glutamate into the interstitial fluid [440]. Given the widespread potential signaling capacities of Ca2+ waves [332], observations of the interactions between astrocytes and neurons in cell culture have suggested that Ca2+ waves play a role in SD initiation and propagation [231,299].
[231] PE. Kunkler, R.P. Kraig, Calcium waves precede electrophysiological changes of spreading depression in hippocampal organ cultures, J. Neurosci. 18 (1998) 3416-3425. [299] M. Nedergaard, Direct signaling from astrocytes to neurons in cultures of mammalian brain cells, Science 263 (1994) 1768-1771. [332] V. Parpura, T.A. Basarsky, F. Liu, K. Jeftinija, S. Jeftinia, P.G. Haydon, Glutamate-mediated astrocyte-neuron signaling, Nature 369 (1994) 744-747. [440] A. Van Harreveld, Two mechanisms for spreading depression in the chicken retina, J. Neurobiol. 9 (1978) 419-431. |
Nothing is marked as a citation. Complements Clg/Fragment_008_04. |
|