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Quelle: Guazzone et al 2005 Seite(n): 603, Zeilen: li.Sp. 2-14 |
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| Acute or chronic inflammation of the male genital tract may result in alterations of spermatogenesis, steroidogenesis and fertility (Bohring and Krause, 2003). Chronic orchitis in men usually occurs as a consequence of different injuries induced by trauma or infectious agents. The interaction of immune cells with spermatic antigens is one of the pathogenic mechanisms involved in testis autoimmunity. Different models of experimental autoimmune orchitis (EAO) have been useful in understanding testicular cell interactions under pathological conditions. EAO has been induced in different species by active immunization with spermatic antigens, by adoptive T cell transfer or by [neonatal thymectomy (Tung and Teuscher, 1995).]
Bohring, C. and Krause, W. (2003) Hum Reprod, 18, 915-24. Tung, K. and Teuscher, C. (1995) Hum Reprod Update, 1, 35-50. |
Acute or chronic inflammation of the male genital tract may result in alterations of spermatogenesis, steroidogenesis and fertility (Hales et al. 1999). Orchitis in men usually occurs as a consequence of different injuries induced by trauma or physical or infectious agents. The interaction of immune cells with spermatic antigens is one of the pathogenic mechanisms involved in testis autoimmunity. Different models of experimental autoimmune orchitis (EAO) have been useful in understanding testicular cell interactions. EAO has been induced in different species by active immunization with spermatic antigens, by adoptive T cell transfer or by neonatal thymectomy (Itoh et al. 1992, Tung et al. 1994).
Hales DB, Diemer T & Hales KH 1999 Role of cytokines in testicular function. Endocrine 10 201–217. Itoh M, Hiramine C, Mukasa A, Tokunaga Y, Fukui Y, Takeuchi Y & Hojo K 1992 Establishment of an experimental model of autoimmune epididymo-orchitis induced by the transfer of a T-cell line in mice. International Journal of Andrology 15 170–181. Tung KSK, Taguchi O & Teuscher C 1994 Testicular and ovarian autoimmune diseases. In Guidebook to Animal Models for Autoimmune Diseases, pp 267–290. Eds IR Cohen & A Millers. New York: Academic Press. |
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