|
|
|
| Untersuchte Arbeit: Seite: 13, Zeilen: 5-19 |
Quelle: Bouchardy et. al. 2003 Seite(n): 3580, Zeilen: Zweiter Satz ff. |
|---|---|
| Breast cancer is primarily a disease of older women and the risk increases with age. In aging populations, breast cancer among the elderly is a major public health concern.
In Switzerland, the Canton of Geneva presents the highest incidence rates of breast cancer in Europe. The life expectancy is particularly high among Swiss women (82.5 years); women aged ≥ 80 years represent 5% of the female population. (56) More than 500 new breast cancers are diagnosed yearly among these women, representing approximately 12% of all breast cancer cases. (69) Despite the increasing number of elderly cancer patients, treatment recommendations for this group are often inconsistent and quite different from those for younger women. (29), (28) Elderly patients are usually excluded from clinical trials, and treatment approaches are therefore influenced by unclear considerations such as the uncertainty about the natural history of disease of [sic] even the physician’s preference. (83), (52) 28.Goldhirsch A, Gelber R, Yothers G, et al. Adjuvant therapy for very young women with breast cancer: Need for tailored treatments. J Natl Cancer Inst Monogr 30:44-51, 2001. 29.Goldhirsch A, Glick J, Gelber R, et al. Meeting highlights: International Consensus Panel on the Treatment of Primary Breast Cancer. J Natl Cancer Inst 90:1601-1608, 1998. 52.Mandelblatt J, Hadley J, Kerner J, et al. Patterns of breast carcinoma treatment in older women: Patient preference and clinical and physical influences. Cancer 89:561-573, 2000. 56.Mémento Statistique de la Suisse 1998. Berne, Switzerland, Office Fédéral de la Statistique, 2000. 69.Rapiti E, Fioretta G, Verkooijen HM, Vlastos G, Schafer P, Sappino AP, Kurtz J, Neyroud-Caspar I, Bouchardy C. Survival of young and older Breast cancer patients in Geneva from 1990 to 2001. Eur J Cancer 41[10], 1446-52. 2005 83.Silliman R, Troyan S, Guadagnoli E, et al. The impact of age, marital status, and physician-patient interactions on the care of older women with breast carcinoma. Cancer 80:1326-1334, 1997. |
It is primarily a disease of older women and the risk increases with age. In aging populations, breast cancer among the elderly is a major public health concern.
In Switzerland, the Canton of Geneva presents the highest incidence rates of breast cancer in Europe.1 The life expectancy is particularly high among Swiss women (82.5 years); women aged ≥ 80 years represent 5% of the female population.2 More than 500 new breast cancers are diagnosed yearly among these women, representing approximately 12% of all breast cancer cases.3 Despite the increasing number of elderly cancer patients, treatment recommendations for this group are often inconsistent and quite different from those for younger women.4,5 Elderly patients are usually excluded from clinical trials,6 and treatment approaches are therefore influenced by unclear considerations such as the uncertainty about the natural history of disease or even the physician’s preference.7,8 1. Parkin DM, Whelan SL, Ferlay J, et al, eds: Cancer Incidence in Five Continents, Vol Vll. Lyon, France, International Agency for Research on Cancer, IARC Scientific Publication 143, 1997 2. Mémento Statistique de la Suisse 1998. Berne, Switzerland, Office Fédéral de la Statistique, 2000 3. Association Suisse des Registres des Tumeurs, 2002. http://www.ASRT.ch 4. Goldhirsch A, Glick JH, Gelber RD, et al: Meeting highlights: International Consensus Panel on the Treatment of Primary Breast Cancer. J Natl Cancer Inst 90:1601-1608, 1998 5. Goldhirsch A, Gelber RD, Yothers G, et al: Adjuvant therapy for very young women with breast cancer: Need for tailored treatments. J Natl Cancer Inst Monogr 30:44-51, 2001 6. Hutchins LF, Unger JM, Crowley JJ, et al: Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med 341:2061-2067, 1999 7. Silliman RA, Troyan SL, Guadagnoli E, et al: The impact of age, marital status, and physician-patient interactions on the care of older women with breast carcinoma. Cancer 80:1326-1334, 1997 8. Mandelblatt JS, Hadley J, Kerner JF, et al: Patterns of breast carcinoma treatment in older women: Patient preference and clinical and physical influences. Cancer 89:561-573, 2000 |
|
|