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| In the case of β-adrenoceptor stimulation, however, RNA elevation is not accompanied by increase in RNA synthesis (Pinson et al., 1993). The mechanism by which β-adrenoceptor stimulation elevates RNA mass seems to be due to a decrease of RNA degradation, which can be mediated by stabilization of RNA by polyamines (Igarashi et al., 1982). Ornithine decarboxylase (ODC) represents the rate-limiting enzyme of polyamine metabolism. ODC is involved in the mechanism by which β-adrenoceptor stimulation elevates cellular RNA mass (Cohen SS., 1998). β-Adrenoceptor-mediated hypertrophy in vivo is also accompanied by induction of ODC (Bartolome et al., 1980).
Bartolome J, Guguenard J, Slotkin TA (1980) Role of ornithine decarboxylase in cardiac growth and hypertrophy. Science 210: 793–794. Cohen SS, Polyamines and the animal cells. In: Cohen SS, editor, A guide to the polyamines, New York: Oxford University Press, 1998, pp. 184–203. Igarashi K, Kakegawa T, Hirose S (1982) Stabilization of 30 S ribosomal subunits of Bacillus subtilis W168 by spermidine and magnesium ions. Biochim Biophys Acta 755:326–331. Pinson A, Schlüter K-D, Zhou XJ, Schwartz P, Kessler-Icekson G and Piper HM (1993) Alpha- and beta-adrenergic stimulation of protein synthesis in cultured adult ventricular cardiomyocytes. J Mol Cell Cardiol 25: 477-490. |
In case of β-adrenoceptor stimulation, however, RNA elevation is not accompanied by an increased 14C-uridine incorporation [7]. That let us conclude that the mechanism by which β-adrenoceptor stimulation elevates RNA mass seems to be due to a decrease of RNA degradation. Since polyamines are known to stabilize RNA [9] this may explain the observed elevation of RNA in the absence of elevated RNA synthesis.
Ornithine decarboxylase (ODC) represents the rate limiting enzyme of the polyamine metabolism. An induction of ODC is causally involved in the mechanism by which β-adrenoceptor stimulation elevates cellular RNA mass [10]. β-Adrenoceptor mediated hypertrophy in vivo is, indeed, accompanied by induction of ODC [5]. [5] Bartolome J, Guguenard J, Slotkin TA. Role of ornithine decarboxylase in cardiac growth and hypertrophy. Science 1980;210:793–794. [7] Pinson A, Schlüter K-D, Zhou XJ, Schwartz P, Kessler-Icekson G, Piper HM. Alpha- and beta-adrenergic stimulation in cultured adult ventricular cardiomyocytes. J Mol Cell Cardiol 1993;25:477–490. [9] Igarashi K, Kakegawa T, Hirose S. Stabilization of 30 S ribosomal subunits of Bacillus subtilis W168 by spermidine and magnesium ions. Biochim Biophys Acta 1982;755:326–331. [10] Cohen SS. Polyamines and the animal cells. In: Cohen SS, editor, A guide to the polyamines, New York: Oxford University Press, 1998, pp. 184–203. |
Wörtliche Übereinstimmung langer Passagen und der Literaturhinweise ohne Kenntlichmachung. |
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