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Untersuchte Arbeit:
Seite: 33, Zeilen: 1 ff. (kpl.)
Quelle: Kazak 2002
Seite(n): 29, Zeilen: 8 ff.
2.7 Klinische Beispiele für Th1- oder Th2- Muster bei humanen Erkrankungen

Bei einer großen Anzahl von Krankheiten kann man eine physiologische bzw. pathophysiologische Th1- oder Th2-Immunantwort beobachten (Tabelle 2).

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1.2.7 Klinische Beispiele für Th1- oder Th2-Muster bei humanen Erkrankungen

Bei einer großen Anzahl von Krankheiten kann man eine physiologische bzw. pathophysiologische Th1- oder Th2-Immunantwort beobachten (Tabelle 4).

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Tabelle 4: Das Überwiegen des Th1- oder Th2-Musters bei humanen Erkrankungen

147. D'Elios, M. M., Manghetti, M., De Carli, M., Costa, F., Baldari, C. T., Burroni, D., Telford, J. L., Romagnani, S. , and Del Prete, G.: T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease. J.Immunol. 158 (2) (1997), S. 962-967

148. Yssel, H., Shanafelt, M. C., Soderberg, C., Schneider, P. V., Anzola, J., and Peltz, G.: Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis. J.Exp.Med. 174 (3) (1991), S. 593-601

149. Parronchi, P., Romagnani, P., Annunziato, F., Sampognaro, S., Becchio, A., Giannarini, L., Maggi, E., Pupilli, C., Tonelli, F., and Romagnani, S.: Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease. Am.J.Pathol. 150 (3) (1997), S. 823-832

150. D'Elios, M. M., Josien, R., Manghetti, M., Amedei, A., De Carli, M., Cuturi, M. C., Blancho, G., Buzelin, F., Del Prete, G., and Soulillou, J. P.: Predominant Th1 cell infiltration in acute rejection episodes of human kidney grafts. Kidney Int. 51 (6) (1997), S. 1876-1884

151. Voskuhl, R. R., Martin, R., Bergman, C., Dalal, M., Ruddle, N. H., and McFarland, H. F.: T helper 1 (Th1) functional phenotype of human myelin basic proteinspecific T lymphocytes. Autoimmunity. 15 (2) (1993), S. 137-143

152. Zipris, D.: Evidence that Th1 lymphocytes predominate in islet inflammation and thyroiditis in the BioBreeding (BB) rat. J.Autoimmun. 9 (3) (1996), S. 315-319

153. Del Prete, G. F., Tiri, A., De Carli, M., Mariotti, S., Pinchera, A., Chretien, I. , Romagnani, S., and Ricci, M.: High potential to tumor necrosis factor alpha (TNFalpha) production of thyroid infiltrating T lymphocytes in Hashimoto's thyroiditis: a peculiar feature of destructive thyroid autoimmunity. Autoimmunity. 4 (4) (1989), S. 267-276

154. Piccinni, M. P. and Romagnani, S.: Regulation of fetal allograft survival by a hormone-controlled Th1- and Th2-type cytokines. Immunol.Res. 15 (2) (1996), S. 141-150

155. Sarih, M., Bouchrit, N., and Benslimane, A.: Different cytokine profiles of peripheral blood mononuclear cells from patients with persistent and selflimited hepatitis C virus infection. Immunol.Lett. 74 (2) (2000), S. 117-120

156. Fan, X. G., Liu, W. E., Li, C. Z., Wang, Z. C., Luo, L. X., Tan, D. M., Hu, G. L., and Zhang, Z.: Circulating Th1 and Th2 cytokines in patients with hepatitis C virus infection. Mediators.Inflamm. 7 (4) (1998), S. 295-297

157. Penna, A., Del Prete, G., Cavalli, A., Bertoletti, A., D'Elios, M. M., Sorrentino, R., D'Amato, M., Boni, C., Pilli, M., Fiaccadori, F., and Ferrari, C.: Predominant Thelper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B. Hepatology 25 (4) (1997), S. 1022-1027

158. De Carli, M., D'Elios, M. M., Mariotti, S., Marcocci, C., Pinchera, A., Ricci, M., Romagnani, S., and Del Prete, G.: Cytolytic T cells with Th1-like cytokine profile predominate in retroorbital lymphocytic infiltrates of Graves' ophthalmopathy. J.Clin.Endocrinol.Metab. 77 ( 5) (1993), S. 1120-1124

159. Dolhain, R. J., van der Heiden, A. N., ter Haar, N. T., Breedveld, F. C., and Miltenburg, A. M.: Shift toward T lymphocytes with a T helper 1 cytokinesecretion profile in the joints of patients with rheumatoid arthritis. Arthritis Rheum. 39 (12) (1996), S. 1961-1969

160. Clerici, M. and Shearer, G. M.: A TH1-->TH2 switch is a critical step in the etiology of HIV infection. Immunol.Today 14 (3) (1993), S. 107-111

161. Caligaris-Cappio, F., Bertero, M. T., Converso, M., Stacchini, A., Vinante, F., Romagnani, S., and Pizzolo, G.: Circulating levels of soluble CD30, a marker of cells producing Th2- type cytokines, are increased in patients with systemic lupus erythematosus and correlate with disease activity. Clin.Exp.Rheumatol. 13 (3) (1995), S. 339-343

162. Cogan, E., Schandene, L., Crusiaux, A., Cochaux, P., Velu, T., and Goldman, M.: Brief report: clonal proliferation of type 2 helper T cells in a man with the hypereosinophilic syndrome. N.Engl.J.Med. 330 (8) (1994), S. 535-538

163. Maggi, E., Biswas, P., Del Prete, G., Parronchi, P., Macchia, D., Simonelli, C., Emmi, L., De Carli, M., Tiri, A., and Ricci, M.: Accumulation of Th-2-like helper T cells in the conjunctiva of patients with vernal conjunctivitis. J.Immunol. 146 (4) (1991), S. 1169-1174

164. Robinson, D. S. and Kay, A. B.: Role of Th1 and Th2 cells in human allergic disorders. Chem.Immunol. 63:187-203 (1996), S. 187-203

165. Scott, P. and Kaufmann, S. H.: The role of T-cell subsets and cytokines in the regulation of infection. Immunol.Today 12 (10) (1991), S. 346-348


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